Pregnancy Teratogenic Effects Category CĪnimal reproduction studies have not been conducted with Nystatin Oral Suspension. There also have been no studies to determine mutagenicity or whether this medication affects fertility in males or females. No long-term animal studies have been performed to evaluate carcinogenic potential. Carcinogenesis, Mutagenesis, Impairment of Fertility
Discontinue treatment if sensitization or irritation is reported during use. This medication is not to be used for the treatment of systemic mycoses. The preparation is contraindicated in patients with a history of hypersensitivity to any of its components. Nystatin Oral Suspension is indicated for the treatment of candidiasis in the oral cavity. Indications and Usage for Nystatin Oral Suspension Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses. Nystatin acts by binding to sterols in the cell membrane of susceptible Candida species with a resultant change in membrane permeability allowing leakage of intracellular components. Generally, resistance does not develop in vivo. Candida albicans demonstrates no significant resistance to nystatin in vitro on repeated subculture in increasing levels of nystatin other Candida species become quite resistant. Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. In patients with renal insufficiency receiving oral therapy with conventional dosage forms, significant plasma concentrations of nystatin may occasionally occur. Most orally administered nystatin is passed unchanged in the stool. Gastrointestinal absorption of nystatin is insignificant. Related/similar drugs fluconazole, nystatin, clotrimazole, Diflucan, itraconazole, miconazole, Mycostatin Nystatin Oral Suspension - Clinical Pharmacology Pharmacokinetics
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